CBGA – Your Full Guide To Cannabigerolic Acid


What is CBGA?

The cannabis plant contains hundreds of different compounds, with THC and CBD being one of the most studied ones.

As you probably already know, THC is famous for its psychoactive effects, known as highs, while CBD is widely used to treat conditions such as epilepsy, anxiety, chronic pain and depression. But there are also hundreds of lesser-known cannabinoids that hold promise in the world of medical marijuana. And one of them is known as CBGA.

CBGA, or cannabigerolic acid, is the acidic form of cannabigerol (CBG). It’s also been dubbed as “the mother of cannabinoids”, due to the fact that THC, CBD and other minor cannabinoids such as CBG would not even exist without CBGA. This is because the cannabis plant uses CBGA as a precursor to creating all of them.

Curious? Keep on reading to learn more about this unique cannabinoid.

What is CBGA?

Let’s take a closer look at what a CBGA is.

CBGA is a plant-derived compound produced to maintain the cannabis plant’s good health and it is also the precursor to many other cannabinoids. Handy, right?

CBGA can be found in the plant’s trichomes and is produced from two organic compounds found in cannabis: geranyl pyrophosphate and olivetolic acid. Working as a protective function for the cannabis plant, CBGA prevents the death of the plant’s cells and helps the plant to maximize energy directed toward the flower.

When marijuana is in its raw form, CBGA can be found in abundance. Although, once the heat is applied to marijuana, the cannabis plant goes through the decarboxylation process and this is where the acidic cannabinoids are transformed into their non-acidic forms.

That said, CBGA is known to produce three major cannabinoid lines:

  • THCA (tetrahydrocannabinolic acid)
  • CBDA (cannabidiolic acid)
  • CBCA (cannabichromenic acid)

As you probably guessed, THCA eventually becomes THC, and CBDA and CBCA are converted to CBD and CBC, respectively.

CBGA is also known to convert to CBG. However, in most cases it will convert to either THC or CBD since they are the most prevalent ones in the world of medical and recreational marijuana.

So you know CBD and THC, but what about CBG?

What is The Difference Between CBD and CBG?

While these two may sound very similar, there are actually some key differences between them.

All cannabinoids that we know first start in their acidic versions. CBDA and THCA are the acidic forms that occur in raw cannabis, and through the process of decarboxylation, they become their non-acidic forms that we all know — CBD and THC.

CBG is also created when the heat is applied to the CBGA molecule. The difference here is that CBG is responsible for producing all the other cannabinoids, while CBD and THC stand on their own.

In addition, there is also a lot of research available on CBD, while the research on CBG potential effects is far more limited.

We also know that CBG can not interact directly with our endocannabinoid system and therefore needs help from THC to affect our receptors. Meanwhile, we also know that CBG is able to interact with the CB1 and CB2 receptors found in our endocannabinoid system and employ its benefits directly.

CBGA’s benefits

CBGA  benefits

Still unsure if you want to give CBGA a try? 

The research on CBGA is still in its infancy, but there have been some promising research studies that found that CBGA could potentially treat a range of conditions. Let’s take a look. 

Cardiovascular Disease

CBGA may help diabetic patients to combat cardiovascular disease.

A study carried out in 2018 to investigate the role of CBGA in treating this disease found that CBGA was able to prevent oxidative stress linked to the development of the disease.

Metabolic Disorders

CBGa may also have therapeutic effects on metabolic disorders.

A recent study, performed in 2019, has found that CBGA is able to activate nuclear peroxisome proliferator-activated receptors (PPARs) that regulate metabolism and prevent chronic metabolic diseases such as diabetes.

Inflammatory Bowel Disease (IBD)

A study from 2013 found that CBG could be used for those who suffer from IBD.

This study was conducted on mice induced with colitis. During their study, the researchers found that CBG helped to reduce the mice’s symptoms. Particularly, CBGA was able to reduce nitric oxide production and the creation of oxidizing agents in the mice.

While more research is definitely needed, it is encouraging that CBGA may treat diseases such as IBD and diabetes. Sounds thrilling, right?

Final Thoughts on CBGA

We hope this article gave you a good idea of what CBGA is and how it may help you.

Research shows that CBGa may have the potential to fight inflammatory issues, cardiovascular complications and diabetes.

Soon, we may also see more research happening on CBGA and its potential benefits. In the meantime, we make sure to keep you in the loop and provide the information you need on CBD and all things cannabis.

This article is not designed for the purpose of dispensing medical advice. Always consult your health practitioner for any medical advice needed. 

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